An agreement has been reached between Iran and six world powers to curb Tehran's nuclear programme in exchange for limited sanctions relief.
The deal, announced by European Union policy chief Catherine Ashton, is a first step towards resolving a decade-old stand-off between Tehran and the West.
The agreement between the Islamic state and the US, Britain, France, Germany, China and Russia was nailed down after more than four days of negotiations in Geneva.
US President Barack Obama said it was an important first step towards a comprehensive solution to Iran's nuclear programme.
Speaking from the White House, Mr Obama said Iran could not use its next-generation centrifuges under the deal and that the substantial limitations under the agreement "cut off Iran's most likely paths to a bomb".
He added that if Iran did not meet its commitments during a six-month period, the US would turn off sanctions relief and "ratchet up the pressure".
"While today's announcement is just a first step, it achieves a great deal," Mr Obama said.
"For the first time in nearly a decade, we have halted the progress of the Iranian nuclear programme, and key parts of the programme will be rolled back."
Iranian President Hassan Rouhani said the deal recognises Tehran's "rights" to maintain a nuclear programme, and it would "never" seek atomic weapons.
The country's Supreme Leader Ayatollah Ali Khamenei said: "This can be the basis for further intelligent actions. Without a doubt the grace of God and the prayers of the Iranian nation were a factor in this success."
Britain's Foreign Secretary William Hague said the agreement was "very important and encouraging", adding that it meant "the nuclear programme won't move forward for six months".
He and US Secretary of State John Kerry are due to have talks in London today on the Iran deal and the latest developments in Syria.
Speaking on Iran's Press TV, Iranian foreign minister Mohammad Javad Zarif said the deal was an opportunity for the West to restore trust with the Iranian nation.
He said Tehran would expand co-operation with the International Atomic Energy Agency, the UN nuclear watchdog, to address what he called some concerns.
But Israel's Cabinet minister for intelligence issues, Yuval Steinitz, said it was a "bad deal" and that last-minute changes to the deal were "far from satisfactory".
"This agreement is still bad and will make it more difficult than before to achieve an appropriate solution in the future," he said.
Instead, he compared it to a failed 2007 international deal with North Korea and said it "is more likely to bring Iran closer to having a bomb".
Iran will get access to $4.2bn (£2.6bn) in foreign exchange as part of the accord, a Western diplomat said.
A senior US official added that the agreement halted progress on Iran's nuclear programme, including construction of the Arak research reactor.
It would neutralise Iran's stockpile of uranium refined to a fissile concentration of 20%, which is a close step away from the level needed for weapons, and calls for intrusive UN nuclear inspections, the official said.
Iran has also committed to stop uranium enrichment above a fissile purity of 5%, a US fact sheet said.
The deal has no recognition of an Iranian right to enrich uranium and sanctions would still be enforced, the US official added.
Refined uranium can be used to fuel nuclear power plants - Iran's stated goal - but also provide the fissile core of an atomic bomb if refined much further.
Diplomacy was stepped up after the landslide election of Hassan Rouhani, a relative moderate, as Iranian president in June, replacing nationalist Mahmoud Ahmadinejad.
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